A look at the most difficult schedules in 2011 (based on opponents' 2010 record).
| Team | Combined win-loss record | Percentage |
|---|---|---|
| 1. Carolina Panthers | 142-114-0 | .555 |
| 2. Buffalo Bills | 137-119-0 | .535 |
| 3t. New York Jets* | 133-123-0 | .520 |
| 3t. Indianapolis Colts* | 133-123-0 | .520 |
| 3t. Jacksonville Jaguars | 133-123-0 | .520 |
| 3t. Kansas City Chiefs* | 133-123-0 | .520 |
| 3t. San Diego Chargers | 133-133-0 | .520 |
| 3t. Denver Broncos | 133-123-0 | .520 |
| 3t. Detroit Lions | 133-123-0 | .520 |
| 10t. Miami Dolphins | 132-124-0 | .516 |
| 10t. Houston Texans | 132-124-0 | .516 |
| 10t. Minnesota Vikings | 132-124-0 | .516 |
| 13t. Green Bay Packers* | 130-126-0 | .508 |
| 13t. New Orleans Saints* | 130-126-0 | .508 |
| 15t. New England Patriots* | 129-127-0 | .504 |
| 15t. Philadelphia Eagles* | 129-127-0 | .504 |
| 15t. Dallas Cowboys | 129-127-0 | .504 |
| 18. Tampa Bay Buccaneers | 127-129-0 | .496 |
| 19t. Cleveland Browns | 126-130-0 | .492 |
| 19t. Oakland Raiders | 126-130-0 | .492 |
| 19t. New York Giants | 126-130-0 | .492 |
| 19t. Atlanta Falcons* | 126-130-0 | .492 |
| 23t. Tennessee Titans | 125-131-0 | .488 |
| 23t. Chicago Bears* | 125-131-0 | .488 |
| 23t. Seattle Seahawks* | 125-131-0 | .488 |
| 26. St. Louis Rams | 122-134-0 | .477 |
| 27t. Pittsburgh Steelers* | 121-135-0 | .473 |
| 27t. Cincinnati Bengals | 121-135-0 | .473 |
| 27t. Washington Redskins | 121-135-0 | .473 |
| 30. San Francisco 49ers | 119-137-0 | .465 |
| 31. Baltimore Ravens* | 117-139-0 | .457 |
| 32. Arizona Cardinals | 113-143-0 | .441 |
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